First-in-class, versatile platform for localized, controlled and sustained
management and treatment of musculoskeletal conditions, in surgical and
non-surgical settings
SIENI is a pioneering biotech company, developing localized therapies to treat inflammation, infection, pain, and prevention of post-surgical complications of musculoskeletal diseases.. Our AEGEAL platform provides sustained and controlled delivery of FDA approved drugs frequently used in treatment of musculoskeletal diseases. Local delivery minimizes systemic exposure — enabling faster healing, safer recovery, and broader applicability across medical disciplines.
Injectable gel delivery platform, developed with validated nanotechnology
Enables localized, sustained drug delivery, directly to injured tissue, at the site of trauma, surgical intervention or treatment
Rapid onset and minimal systemic effects
Adaptable across orthopedic, trauma, burn, and other applications
Potential for both human and veterinary use
Sustained and programmable release 3-14 day delivery
Single dose – single administration improves compliance and avoids multiple interventions
Multimodal action loaded with 1+ APIs of proven efficacy
Local administration to affected tissue decreased systemic exposure
Higher tolerability and improved safety profile
Injectable gel delivery platform, developed with validated nanotechnology
Enables localized, sustained drug delivery, directly to injured tissue, at the site of trauma, surgical intervention or treatment
Rapid onset and minimal systemic effects
Adaptable across orthopedic, trauma, burn, and other applications
Potential for both human and veterinary use
Sustained and programmable release 3-14 day delivery
Single dose – single administration improves compliance and avoids multiple interventions
Multimodal action loaded with 1+ APIs of proven efficacy
Local administration to affected tissue decreased systemic exposure
Higher tolerability and improved safety profile
“AEGEAL is for every knee and hip replacement surgery.”
“AEGEAL is for every knee and hip replacement surgery.”
“AEGEAL is for every knee and hip replacement surgery.”
“AEGEAL is for every knee and hip replacement surgery.”
“AEGEAL is for every knee and hip replacement surgery.”
“AEGEAL is for every knee and hip replacement surgery.”
of the world suffers from
musculoskeletal conditions
annual cost in the U.S.
healthcare system
Significant growth driven by
aging population, trauma,
and competitive sports
Existing biologics set >$1B
revenue precedents
